Incorporating Genetic Biomarkers into Predictive Models of Normal Tissue Toxicity

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Incorporating Genetic Biomarkers into Predictive Models of Normal Tissue Toxicity.

There is considerable variation in the level of toxicity patients experience for a given dose of radiotherapy, which is associated with differences in underlying individual normal tissue radiosensitivity. A number of syndromes have a large effect on clinical radiosensitivity, but these are rare. Among non-syndromic patients, variation is less extreme, but equivalent to a ±20% variation in dose....

متن کامل

Incorporating biological, chemical, and toxicological knowledge into predictive models of toxicity.

Thomas et al. (2012) recently published an evaluation of statistical models for classifying in vivo toxicity endpoints from ToxRefDB (Knudsen et al., 2009; Martin et al., 2009a, b) using ToxCast in vitro bioactivity data (Judson et al., 2010) and chemical structure descriptors. We commend the authors for a thorough assessment of statistical tools for uncovering patterns of associations among th...

متن کامل

Incorporating prognostic imaging biomarkers into clinical practice

A prognostic imaging biomarker can be defined as an imaging characteristic that is objectively measurable and provides information on the likely outcome of the cancer disease in an untreated individual and should be distinguished from predictive imaging biomarkers and imaging markers of response. A range of tumour characteristics of potential prognostic value can be measured using a variety ima...

متن کامل

Incorporating Choice into Models of Technology Adoption

Research investigating technology adoption has assumed that the individual accepting the technology has only one technology in mind when making their adoption decision. Models such as the UTAUT, TAM, PCI assume that the decision whether or not to adopt the technology occurs within a bubble – there is no explicit understanding in these models that no other technologies exist outside of the one t...

متن کامل

Towards a Vocabulary for Incorporating Predictive Models into the Linked Data Web

Predictive modeling reflects the process of using data and statistical or data mining methods for predicting new observations. The predictive models that are created out of this process could be reused in different applications in the same sense that open data is reused. Towards this end, a few standards have been proposed in order to enable transfer of predictive models across platforms and ap...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Clinical Oncology

سال: 2015

ISSN: 0936-6555

DOI: 10.1016/j.clon.2015.06.013